FROM STUDIES OF BIOCHEMICAL MECHANISMS TO NEW BIOLOGICAL MEDIATORS: PROSTAGLANDIN ENDOPEROXIDES, THROMBOXANES, AND LEUKOTRIENES

@article{Samuelsson1984FROMSO,
  title={FROM STUDIES OF BIOCHEMICAL MECHANISMS TO NEW BIOLOGICAL MEDIATORS: PROSTAGLANDIN ENDOPEROXIDES, THROMBOXANES, AND LEUKOTRIENES},
  author={Bengt Bertil Samuelsson},
  journal={ChemInform},
  year={1984},
  volume={15}
}
Following the completion of the structural work on the prostaglandins with Sune Bergstrom and co-workers (for reviews, see refs. l-3) I was very fortunate in being able to spend a year in the Chemistry Department at Harvard University, Cambridge, Mass. During this stay I had the opportunity to study both theoretical and synthetic organic chemistry. The year in Cambridge had a profound effect on my future research. At this time Konrad Bloch, E.J. Corey, Frank Westheimer, Robert B. Woodward and… 

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References

SHOWING 1-10 OF 33 REFERENCES
"J."
however (for it was the literal soul of the life of the Redeemer, John xv. io), is the peculiar token of fellowship with the Redeemer. That love to God (what is meant here is not God’s love to men)
Prostaglandin synthetase inhibitors.
  • M. Henzl
  • Medicine
    Obstetrics and gynecology
  • 1984
in ' Advances in Prostaglandin , Thromboxane and Leukotriene Research ' ( Samuelsson B , Ramwell P &
  • 1983
in ' Advances in Prostaglandin , Thromboxane and Leukotriene Research ( Samuelsson B &
  • 1983
in ' Advances in Prostaglandin , Thromboxane and Leukotriene Research ' ( Samuelsson B &
  • 1982
in ' Advances in Prostaglandin , Thromboxane and Leukotriene Research ( Samuelsson B , Ramwell P & Paoletti 9 eds )
  • 1982
) Prostaglandins 19 , 645 . Bernstr ~ m K & HammarstrSm S ( 1981 )
  • J . Biol . Chem .
  • 1980
Acta Physiol
  • Scand. 96, 145
  • 1976
Advances in prostaglandin and thromboxane research
Tetr
  • Lett. 37, 3275
  • 1976
...
1
2
3
4
...