FRET detection of cellular alpha4-integrin conformational activation.

Abstract

Integrins are cell adhesion receptors, expressed on every cell type, that have been postulated to undergo conformational changes upon activation. Here, different affinity states were generated by exposing alpha4-integrins to divalent ions or by inside-out activation using a chemokine receptor. We probed the dynamic structural transformation of the integrin… (More)

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Cite this paper

@article{Chigaev2003FRETDO, title={FRET detection of cellular alpha4-integrin conformational activation.}, author={Alexandre Chigaev and Tione Buranda and Denise C. Dwyer and Eric R Prossnitz and Larry A. Sklar}, journal={Biophysical journal}, year={2003}, volume={85 6}, pages={3951-62} }