FRAXA and FRAXE: evidence against segregation distortion and for an effect of intermediate alleles on learning disability.

@article{Teague1998FRAXAAF,
  title={FRAXA and FRAXE: evidence against segregation distortion and for an effect of intermediate alleles on learning disability.},
  author={Jon W. Teague and Newton E. Morton and Nick R. Dennis and Greta Curtis and Nicol M. McKechnie and James N Macpherson and Anne Murray and Michelle C Pound and Andrea J Sharrock and Sheila A Youings and Patricia A. Jacobs},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 2},
  pages={719-24}
}
There have been several claims of segregation distortion (meiotic drive) for loci associated with diseases caused by trinucleotide repeats, leading us to test for this phenomenon in a large study of the X-linked loci FRAXA and FRAXE. We found no evidence of meiotic drive in females and no convincing evidence in males, where the limitation of risk to daughters creates a testing bias for alleles of interest. Alleles for pre- and full mutation, intermediate alleles, and common alleles were… CONTINUE READING