FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse.

@article{Hentges2001FRAPmTORIR,
  title={FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse.},
  author={Kathryn E. Hentges and B Sirry and A C Gingeras and Dos D. Sarbassov and Nahum Sonenberg and David Baltimore Walter Neupert G{\"u}nter Blobel George Pala Sabatini and Andrew S. Peterson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 24},
  pages={13796-801}
}
The FKBP-12-rapamycin associated protein (FRAP, also known as mTOR and RAFT-1) is a member of the phosphoinositide kinase related kinase family. FRAP has serine/threonine kinase activity and mediates the cellular response to mitogens through signaling to p70s6 kinase (p70(s6k)) and 4E-BP1, resulting in an increase in translation of subsets of cellular mRNAs. Translational up-regulation is blocked by inactivation of FRAP signaling by rapamycin, resulting in G(1) cell cycle arrest. Rapamycin is… CONTINUE READING