FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites.

@article{Wilke1996FRA3BEO,
  title={FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites.},
  author={Cailin Moira Wilke and Bryan K. Hall and Alma Hoge and William J Paradee and David I. Smith and Thomas W. Glover},
  journal={Human molecular genetics},
  year={1996},
  volume={5 2},
  pages={187-95}
}
The common fragile site at 3p14.2 (FRA3B) is the most sensitive site on normal human chromosomes for the formation of gaps and breaks when DNA replication is perturbed by aphidicolin or folate stress. Although rare fragile sites are known to arise through the expansion of CCG repeats, the mechanism responsible for common fragile sites is unknown. Beyond being a basic component of chromosome structure, no biological effects of common fragile sites have been convincingly shown, although… CONTINUE READING
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