FRA3B and other common fragile sites: the weakest links

@article{Huebner2001FRA3BAO,
  title={FRA3B and other common fragile sites: the weakest links},
  author={Kay Huebner and Carlo M. Croce},
  journal={Nature Reviews Cancer},
  year={2001},
  volume={1},
  pages={214-221}
}
  • Kay Huebner, Carlo M. Croce
  • Published in Nature Reviews Cancer 2001
  • Medicine, Biology
  • In 1979, the first chromosome alteration associated with familial cancer was reported. Five years later, a fragile site was observed in the same chromosome region. The product of the fragile histidine triad (FHIT) gene, which encompasses this fragile site, is partially or entirely lost in most human cancers, indicating that it has a tumour-suppressor function. Inactivation of only one FHIT allele compromises this suppressor function, indicating that a 'one-hit' mechanism of tumorigenesis is… CONTINUE READING

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