FRA-1 proto-oncogene induces lung epithelial cell invasion and anchorage-independent growth in vitro, but is insufficient to promote tumor growth in vivo.

@article{Adiseshaiah2007FRA1PI,
  title={FRA-1 proto-oncogene induces lung epithelial cell invasion and anchorage-independent growth in vitro, but is insufficient to promote tumor growth in vivo.},
  author={Pavan Adiseshaiah and Daniel J. Lindner and Dhananjaya V. Kalvakolanu and Sekhar P. M. Reddy},
  journal={Cancer research},
  year={2007},
  volume={67 13},
  pages={6204-11}
}
FRA-1 forms activator protein-1 complexes in association with members of the JUN family and drives gene transcription. FRA-1 has been implicated in the development of airway squamous metaplasia and is frequently overexpressed in squamous cell carcinomas of the esophagus and stomach. We and others have shown a high level of persistent induction of FRA-1 by lung carcinogens, such as cigarette smoke and asbestos, in pulmonary epithelial cells. However, the exact roles of FRA-1 in regulating lung… CONTINUE READING

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