FR901228, an inhibitor of histone deacetylases, increases the cellular responsiveness to IL-6 type cytokines by enhancing the expression of receptor proteins

@article{Blanchard2002FR901228AI,
  title={FR901228, an inhibitor of histone deacetylases, increases the cellular responsiveness to IL-6 type cytokines by enhancing the expression of receptor proteins},
  author={Fr{\'e}d{\'e}ric Blanchard and Erin Kinzie and Yanping Wang and Laurence Duplomb and Anne Godard and W. Held and Bonnie B. Asch and Heinz Baumann},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={6264-6277}
}
The related members of the interleukin-6 (IL-6) family of cytokines, leukemia inhibitory factor (LIF), oncostatin M (OSM) and IL-6 are inflammatory mediators that control differentiated cell functions as well as proliferation. The cellular responsiveness to these cytokines is largely determined by the expression of the appropriate receptor proteins. The receptor expression profile for each cell type is established during differentiation and is often altered during oncogenic transformation… CONTINUE READING
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