FR220897 and FR220899, Novel Antifungal Lipopeptides from Coleophoma empetri No. 14573

@article{Kanasaki2006FR220897AF,
  title={FR220897 and FR220899, Novel Antifungal Lipopeptides from Coleophoma empetri No. 14573},
  author={Ryuichi Kanasaki and Fumie Abe and Motoo Kobayashi and Masaaki Katsuoka and Michizane Hashimoto and Shigehiro Takase and Yasuhisa Tsurumi and Akihiko Fujie and Motohiro Hino and Seiji Hashimoto and Yasuhiro Hori},
  journal={The Journal of Antibiotics},
  year={2006},
  volume={59},
  pages={149-157}
}
Novel antifungal lipopeptides, FR220897 and FR220899, were isolated from the fermentation broth of a fungal strain No. 14573. This strain was identified as Coleophoma empetri No. 14573 from morphological and physiological characteristics. FR220897 and FR220899 showed antifungal activities against Aspergillus fumigatus and Candida albicans attributed to inhibition of 1,3-β-glucan synthesis. Furthermore, FR220897 was effective in a murine model of systemic candidiasis. 

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