FR discrimination training reverses 6-hydroxydopamine-induced striatal dopamine depletion in a rat model of Lesch-Nyhan syndrome.

@article{Stodgell1996FRDT,
  title={FR discrimination training reverses 6-hydroxydopamine-induced striatal dopamine depletion in a rat model of Lesch-Nyhan syndrome.},
  author={Chris J Stodgell and Stephen R. Schroeder and Richard E. Tessel},
  journal={Brain research},
  year={1996},
  volume={713 1-2},
  pages={246-52}
}
Five-day-old rats received 6-hydroxydopamine (6-HD; 100 micrograms base) or vehicle intracisternally. Striatal and cortical dopamine (DA) and metabolite levels were then determined when animals were three or 8.5 months of age and the latter rats had been weight-reduced for 5.5 months. In the latter animals these determinations were made 1 month following 4… CONTINUE READING