FPR2: A Novel Promising Target for the Treatment of Influenza

@inproceedings{Alessi2017FPR2AN,
  title={FPR2: A Novel Promising Target for the Treatment of Influenza},
  author={Marie-Christine Alessi and Nicolas Cenac and Mustapha Si-Tahar and B{\'e}atrice Riteau},
  booktitle={Front. Microbiol.},
  year={2017}
}
The Formyl-peptide receptor-2 (FPR2) is a seven transmembrane G protein-coupled receptor, which plays an important role in sensing of bacteria and modulation of immune responses. FPR2 is also used by viruses for their own profit. Annexin A1, one of the multiple ligands of FPR2, is incorporated in the budding virus membrane of influenza A viruses (IAV). Thereby, once IAV infect a host cell, FPR2 is activated. FPR2-signaling leads to an increase in viral replication, a dysregulation of the host… CONTINUE READING
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