FOXQ1 regulates epithelial-mesenchymal transition in human cancers.

  title={FOXQ1 regulates epithelial-mesenchymal transition in human cancers.},
  author={Yuanyuan Qiao and Xia Jiang and Shuet Theng Lee and Radha Krishna Murthy Karuturi and Shing Chuan Hooi and Qiang Yu},
  journal={Cancer research},
  volume={71 8},
Epithelial-mesenchymal transition (EMT) in cancer cells plays a pivotal role in determining metastatic prowess, but knowledge of EMT regulation remains incomplete. In this study, we defined a critical functional role for the Forkhead transcription factor FOXQ1 in regulating EMT in breast cancer cells. FOXQ1 expression was correlated with high-grade basal-like breast cancers and was associated with poor clinical outcomes. RNAi-mediated suppression of FOXQ1 expression in highly invasive human… CONTINUE READING
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