FOXQ1 promotes gastric cancer metastasis through upregulation of Snail.

@article{Zhang2016FOXQ1PG,
  title={FOXQ1 promotes gastric cancer metastasis through upregulation of Snail.},
  author={Jing Zhang and Yimin Liu and Jia Zhang and Xiao-hai Cui and Gang Li and Jiansheng Wang and Hong Ren and Yunfeng Zhang},
  journal={Oncology reports},
  year={2016},
  volume={35 6},
  pages={
          3607-13
        }
}
Gastric cancer (GC) is one of the most common cancers, and the second most common cause of cancer deaths worldwide. Forkhead box Q1 (FOXQ1) is a member of the forkhead transcription factor family and its upregulation is closely correlated with tumor progression and prognosis of multiple cancer types, including GC. FOXQ1 has been shown to regulate EMT and function in human cancers. However, the role of FOXQ1 in regulating EMT in GC and the exactly mechanism has not been clarified. The purpose of… 
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Tumor-associated macrophages induce the expression of FOXQ1 to promote epithelial-mesenchymal transition and metastasis in gastric cancer cells
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Evidence is provided that TAMs promote EMT, invasion and migration of GC cells via FOXQ1, and the TAM/FOXQ1 axis may represent a novel target for GC cells.
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TLDR
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TLDR
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TLDR
It is demonstrated that knockdown of Snail can inhibit the EMT process of LSCC cells through the VDR signaling pathway in vitro by demonstrating the knockdown efficiency by Western blotting and real-time PCR.
Downregulation of miR-519d-3p is Associated with Poor Outcomes and Facilitates Tumor Progression in Papillary Thyroid Cancer by Regulating FOXQ1.
  • Pihong Li, Xiaoyun Pan, +4 authors Mingdong Lu
  • Biology, Chemistry
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2021
TLDR
The decreased expression of miR-519d-3p was associated with reduced overall survival and progression-free survival of patients, and the miR/FOXQ1 axis mediated PTC tumor progression from cell proliferation, migration, and invasion in PTC cells.
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