FOXP3+ regulatory T cells and tumoral indoleamine 2,3-dioxygenase expression predicts the carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas.

Abstract

BACKGROUND AND AIMS FOXP3+ regulatory T cells (Tregs) play a central role in self-tolerance and suppress the effective antitumor immune response. A recent study revealed that indoleamine 2,3-dioxygenase (IDO)-mediated tryptophan depletion was able to affect local tumor-infiltrating lymphocytes. The aim of this study was to investigate the clinical… (More)
DOI: 10.1159/000308966

Topics

Cite this paper

@article{Kobayashi2010FOXP3RT, title={FOXP3+ regulatory T cells and tumoral indoleamine 2,3-dioxygenase expression predicts the carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas.}, author={Noritoshi Kobayashi and Kensuke Kubota and Shingo Kato and Seitaro Watanabe and Takeshi Shimamura and Hiroyuki Kirikoshi and Satoru Saito and Michio Ueda and Itaru Endo and Yoshiaki Inayama and Shin Maeda and Atsushi Nakajima}, journal={Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]}, year={2010}, volume={10 5}, pages={631-40} }