FOXP3 expression and prognosis: role of both the tumor and T cells.

@article{Lu2009FOXP3EA,
  title={FOXP3 expression and prognosis: role of both the tumor and T cells.},
  author={Hailing Lu},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2009},
  volume={27 11},
  pages={1735-6}
}
FOXP3 is a transcription factor that is well known to be the hallmark of immune suppressive T regulatory cells (Tregs), especially thymically derived natural Tregs. Lack of FOXP3-expressing T cells can lead to autoimmune disease, whereas an abundance of FOXP3expressing T cells can result in immune deficiency. Increased levels of FOXP3-positive Tregs in peripheral blood and tumor have been reported in patients with various types of cancer, including ovarian, breast, and other tumors. Abundance… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 13 references

Similar Papers

Loading similar papers…