FOXP3 ensembles in T‐cell regulation

@article{Li2006FOXP3EI,
  title={FOXP3 ensembles in T‐cell regulation},
  author={Bin Li and Arabinda Samanta and Xiaomin Song and Keiji Furuuchi and Kathryn T. Iacono and Sarah Kennedy and Makoto Katsumata and Sandra J. Saouaf and Mark Irwin Greene},
  journal={Immunological Reviews},
  year={2006},
  volume={212}
}
Summary:  Our recent studies have identified dynamic protein ensembles containing forkhead box protein 3 (FOXP3) that provide insight into the molecular complexity of suppressor T‐cell activities, and it is our goal to determine how these ensembles regulate FOXP3's transcriptional activity in vivo. In this review, we summarize our current understanding of how FOXP3 expression is induced and how FOXP3 functions in vivo as a transcriptional regulator by assembling a multisubunit complex involved… 
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Foxp3 directly or as part of a multimeric complex engages with the NF-κB component c-Rel, and it is demonstrated that the N-terminal region of Foxp3 is required for the binding of c-rel, but not NFAT.
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