FOXP3 ensembles in T‐cell regulation

@article{Li2006FOXP3EI,
  title={FOXP3 ensembles in T‐cell regulation},
  author={Bin Li and Arabinda Samanta and Xiaomin Song and Keiji Furuuchi and Kathryn T. Iacono and Sarah Kennedy and Makoto Katsumata and Sandra J. Saouaf and Mark Irwin Greene},
  journal={Immunological Reviews},
  year={2006},
  volume={212}
}
Summary:  Our recent studies have identified dynamic protein ensembles containing forkhead box protein 3 (FOXP3) that provide insight into the molecular complexity of suppressor T‐cell activities, and it is our goal to determine how these ensembles regulate FOXP3's transcriptional activity in vivo. In this review, we summarize our current understanding of how FOXP3 expression is induced and how FOXP3 functions in vivo as a transcriptional regulator by assembling a multisubunit complex involved… 
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
TLDR
Evidence is highlighted suggesting that epigenetic regulation of the FOXP3 locus contributes to its role as a lineage-specification factor in regulatory T (TReg) cells.
The Role of FOXP3 in Regulating Immune Responses
TLDR
The cooperative roles of FOXP3 and other T-cell lineage-defining transcription factors are dissected and it is discussed how these networks not only control the ability to Tregs to suppress different types of immune responses, but also enable Treg plasticity.
Forkhead box protein 3: essential immune regulatory role.
FOXP3 and its partners: structural and biochemical insights into the regulation of FOXP3 activity
TLDR
Structural information on FOXP3 complex may offer novel functional insights, as well as facilitate the development of rational means to modulate regulatory T-cell function in various human diseases.
FOXP3 Actively Represses Transcription by Recruiting the HAT/HDAC Complex
TLDR
This work found FOXP3 could actively repress transcription by recruiting distinct histone acetyltransferases and histone deacetylases to function as a corepressor complex and the identification of enzymatic factors operative as essential participants in FoxP3-mediated transcriptional repression provides a practical basis for therapeutically modulating the activity of FOXP 3 in immune suppression.
Yin–Yang Regulation of RORγt Protein Complex in Th17 Differentiation
TLDR
Recent progress in research investigating the interaction of RORγt with potential partners is summarized, highlighting detailed mechanisms that direct Th17 cell differentiation and potential therapeutic targets in inflammatory diseases.
Foxp3 Interacts with c-Rel to Mediate NF-κB Repression
TLDR
Foxp3 directly or as part of a multimeric complex engages with the NF-κB component c-Rel, and it is demonstrated that the N-terminal region of Foxp3 is required for the binding of c-rel, but not NFAT.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 170 REFERENCES
Forkhead transcription factors in immunology
TLDR
The forkhead genes promise insight into the mechanisms of immunoregulation in several immune cell lineages, and their dysregulation likely contributes to the pathogenesis of several immunological disorders, suggesting that their study will lead to the development of novel therapeutic agents.
Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation*
TLDR
The findings indicate that the ability of scurfin to bind DNA, and presumably repress transcription, plays a paramount role in determining the amplitude of the response of CD4 T cells to activation.
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
TLDR
Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells and retroviral gene transfer of Foxp3 converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+.
Transcription factors in autoimmunity.
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
TLDR
Principal advances in the understanding of the molecular mechanisms of Treg cell development and function are discussed with particular emphasis on the forkhead transcription factor Foxp3.
Forkhead-box transcription factors and their role in the immune system
TLDR
This review focuses on FOXP3, FOXN1, FOXJ1 and members of the FOXO subfamily and their function in the immune system.
Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions
TLDR
Analysis of the N-terminal repression domain in Foxp1, Foxp2, and Foxp4 shows that this region contains two separate and distinct repression subdomains that are highly homologous termed subdomain 1 and sub domain 2, however, subdomain 2 is not functional in Fox p4.
Multiple Domains Define the Expression and Regulatory Properties of Foxp1 Forkhead Transcriptional Repressors*
TLDR
The Foxp subfamily of forkhead/HNF3 transcription factors has recently been recognized because of its involvement in autoimmune disease, speech and language disorders, and lung development and it is demonstrated that Foxp1, although broadly expressed, is further regulated by tissue-specific alternative splicing of these functionally important sequence domains.
The Role of Brg1, a Catalytic Subunit of Mammalian Chromatin-remodeling Complexes, in T Cell Development
TLDR
A role for Brg1 complexes in the regulation of thymocyte cell proliferation and survival is established and the importance of chromatin-remodeling complexes at different stages in the development of a mammalian cell lineage is highlighted.
...
1
2
3
4
5
...