FOXP3: required but not sufficient. the role of GARP (LRRC32) as a safeguard of the regulatory phenotype.

@article{ProbstKepper2010FOXP3RB,
  title={FOXP3: required but not sufficient. the role of GARP (LRRC32) as a safeguard of the regulatory phenotype.},
  author={Michael Probst-Kepper and Rudi Balling and Jan Buer},
  journal={Current molecular medicine},
  year={2010},
  volume={10 6},
  pages={533-9}
}
FOXP3 is essential for the development and function of regulatory CD4(+)CD25(hi) T (T(reg)) cells. However, recent evidence suggests that FOXP3 alone is not sufficient to completely explain the regulatory phenotype of these key players in autoimmunity and inflammation: after being activated, conventional human CD4(+) T cells transiently up-regulate FOXP3… CONTINUE READING