FOXP3: genetic and epigenetic implications for autoimmunity.

@article{Katoh2013FOXP3GA,
  title={FOXP3: genetic and epigenetic implications for autoimmunity.},
  author={Hiroto Katoh and Pan Zheng and Yang Liu},
  journal={Journal of autoimmunity},
  year={2013},
  volume={41},
  pages={72-8}
}
FOXP3 plays an essential role in the maintenance of self-tolerance and, thus, in preventing autoimmune diseases. Inactivating mutations of FOXP3 cause immunodysregulation, polyendocrinopathy, and enteropathy, X-linked syndrome. FOXP3-expressing regulatory T cells attenuate autoimmunity as well as immunity against cancer and infection. More recent studies demonstrated that FOXP3 is an epithelial cell-intrinsic tumor suppressor for breast, prostate, ovary and other cancers. Corresponding to its… CONTINUE READING
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