FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive-type patients.

@article{Iwase2009FOXP3ScurfinGP,
  title={FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive-type patients.},
  author={Kyoko Iwase and Akira Shimada and Toshihide Kawai and Yoshiaki Okubo and Yasuhiko Kanazawa and Junichiro Irie and Yoichi Oikawa and Hiroshi Hirose and Taro Maruyama and Hiroshi Itoh},
  journal={Autoimmunity},
  year={2009},
  volume={42 2},
  pages={159-67}
}
PURPOSE Some reports have shown that the cause of type 1 diabetes is associated with dysfunction of regulatory T cells (Tregs). The FOXP3/Scurfin gene is known to be a master gene of Tregs. Therefore, we tried to analyze the relation between the gene polymorphism and adult onset type 1 diabetes and its subtype in the Japanese population. METHODS In this… CONTINUE READING