FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy.

  title={FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy.},
  author={Willem S. Lexmond and Jeremy A Goettel and Jonathan J Lyons and Justin Jacobse and Marion M. Deken and Monica G Lawrence and Thomas Dimaggio and Daniel Kotlarz and Elizabeth K Garabedian and Paul Sackstein and Celeste C Nelson and Nina Jones and Kelly D. Stone and Fabio Candotti and Edmond H. H. M. Rings and Adrian J. Thrasher and Joshua D. Milner and Scott B. Snapper and Edda Fiebiger},
  journal={The Journal of clinical investigation},
  volume={126 10},
In addition to the infectious consequences of immunodeficiency, patients with Wiskott-Aldrich syndrome (WAS) often suffer from poorly understood exaggerated immune responses that result in autoimmunity and elevated levels of serum IgE. Here, we have shown that WAS patients and mice deficient in WAS protein (WASP) frequently develop IgE-mediated reactions to common food allergens. WASP-deficient animals displayed an adjuvant-free IgE-sensitization to chow antigens that was most pronounced for… CONTINUE READING


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