FOXP2 and the neuroanatomy of speech and language

  title={FOXP2 and the neuroanatomy of speech and language},
  author={Faraneh Vargha-Khadem and David G. Gadian and Andrew J. Copp and Mortimer M. Mishkin},
  journal={Nature Reviews Neuroscience},
That speech and language are innate capacities of the human brain has long been widely accepted, but only recently has an entry point into the genetic basis of these remarkable faculties been found. The discovery of a mutation in FOXP2 in a family with a speech and language disorder has enabled neuroscientists to trace the neural expression of this gene during embryological development, track the effects of this gene mutation on brain structure and function, and so begin to decipher that part… 

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It is shown that human FOXP2 contains changes in amino-acid coding and a pattern of nucleotide polymorphism, which strongly suggest that this gene has been the target of selection during recent human evolution.

FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder.

The homologous pattern of FOXP2/Foxp2 expression in human and mouse argues for a role for this gene in development of motor-related circuits throughout mammalian species.

Expression of Foxp2, a gene involved in speech and language, in the developing and adult striatum

The striatum is known to be involved in the process of procedural memory, and mutation of Foxp2 results in neurological disorders of language and speech, so the striatum, particularly the striosomal system, may participate in neural information processing for language and Speech.

Praxic and nonverbal cognitive deficits in a large family with a genetically transmitted speech and language disorder.

Investigations of the same KE family indicate that the inherited disorder has a broad phenotype which transcends impaired generation of syntactical rules and includes a striking articulatory impairment as well as defects in intellectual, linguistic, and orofacial praxic functions generally.

Language fMRI abnormalities associated with FOXP2 gene mutation

The affected members of the KE family showed significant underactivation relative to the unaffected members in Broca's area and its right homolog, as well as in other cortical language-related regions and in the putamen.

Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia.

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A forkhead-domain gene is mutated in a severe speech and language disorder

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Neural basis of an inherited speech and language disorder.

The genetic mutation or deletion in this region has resulted in the abnormal development of several brain areas that appear to be critical for both orofacial movements and sequential articulation, leading to marked disruption of speech and expressive language.

Parallel FoxP1 and FoxP2 Expression in Songbird and Human Brain Predicts Functional Interaction

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MRI analysis of an inherited speech and language disorder: structural brain abnormalities.

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