FOXP2 and the neuroanatomy of speech and language

@article{VarghaKhadem2005FOXP2AT,
  title={FOXP2 and the neuroanatomy of speech and language},
  author={F. Vargha-Khadem and D. Gadian and A. Copp and M. Mishkin},
  journal={Nature Reviews Neuroscience},
  year={2005},
  volume={6},
  pages={131-138}
}
That speech and language are innate capacities of the human brain has long been widely accepted, but only recently has an entry point into the genetic basis of these remarkable faculties been found. The discovery of a mutation in FOXP2 in a family with a speech and language disorder has enabled neuroscientists to trace the neural expression of this gene during embryological development, track the effects of this gene mutation on brain structure and function, and so begin to decipher that part… Expand
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References

SHOWING 1-10 OF 48 REFERENCES
Molecular evolution of FOXP2, a gene involved in speech and language
TLDR
It is shown that human FOXP2 contains changes in amino-acid coding and a pattern of nucleotide polymorphism, which strongly suggest that this gene has been the target of selection during recent human evolution. Expand
FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder.
TLDR
The homologous pattern of FOXP2/Foxp2 expression in human and mouse argues for a role for this gene in development of motor-related circuits throughout mammalian species. Expand
Expression of Foxp2, a gene involved in speech and language, in the developing and adult striatum
TLDR
The striatum is known to be involved in the process of procedural memory, and mutation of Foxp2 results in neurological disorders of language and speech, so the striatum, particularly the striosomal system, may participate in neural information processing for language and Speech. Expand
Praxic and nonverbal cognitive deficits in a large family with a genetically transmitted speech and language disorder.
TLDR
Investigations of the same KE family indicate that the inherited disorder has a broad phenotype which transcends impaired generation of syntactical rules and includes a striking articulatory impairment as well as defects in intellectual, linguistic, and orofacial praxic functions generally. Expand
Language fMRI abnormalities associated with FOXP2 gene mutation
TLDR
The affected members of the KE family showed significant underactivation relative to the unaffected members in Broca's area and its right homolog, as well as in other cortical language-related regions and in the putamen. Expand
Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia.
TLDR
Investigations of the KE family, half the members of which are affected by a severe disorder of speech and language, are reported, suggesting that, in the affected family members, the verbal and non-verbal deficits arise from a common impairment in the ability to sequence movement or in procedural learning. Expand
A forkhead-domain gene is mutated in a severe speech and language disorder
TLDR
It is suggested that the gene FOXP2, which encodes a putative transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain, is involved in the developmental process that culminates in speech and language. Expand
Neural basis of an inherited speech and language disorder.
TLDR
The genetic mutation or deletion in this region has resulted in the abnormal development of several brain areas that appear to be critical for both orofacial movements and sequential articulation, leading to marked disruption of speech and expressive language. Expand
Parallel FoxP1 and FoxP2 Expression in Songbird and Human Brain Predicts Functional Interaction
TLDR
In situ hybridization analyses for FoxP1 and FoxP2 in a songbird reveal a corticostriatal expression pattern congruent with the abnormalities in brain structures of affected KE family members, suggesting combinatorial regulation by these molecules during neural development and within vocal control structures may occur. Expand
MRI analysis of an inherited speech and language disorder: structural brain abnormalities.
TLDR
The results provide further evidence of a relationship between the abnormal development of this nucleus and the impairments in oromotor control and articulation reported in the KE family. Expand
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3
4
5
...