FOXP 3 Controls an miR-146 / NFk B Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells

@inproceedings{Liu2015FOXP3C,
  title={FOXP 3 Controls an miR-146 / NFk B Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells},
  author={Runhua Liu and Cong Liu and Dongquan Chen and Wei-Hsiung Yang and Xiuping Liu and Chang-gong Liu and Courtney M. Dugas and Fei Tang and Pan Zheng and Yang Liu and Lizhong Wang},
  year={2015}
}
FOXP3 functions not only as the master regulator in regulatory T cells, but also as an X-linked tumor suppressor. The tumorsuppressive activity of FOXP3 has been observed in tumor initiation, but its role during tumor progression remains controversial. Moreover, the mechanism of FOXP3-mediated tumorsuppressive activity remains largely unknown. Using chromatin immunoprecipitation (ChIP) sequencing, we identified a series of potential FOXP3-targeted miRNAs in MCF7 cells. Notably, FOXP3… CONTINUE READING

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