FOXOs: signalling integrators for homeostasis maintenance

@article{Eijkelenboom2013FOXOsSI,
  title={FOXOs: signalling integrators for homeostasis maintenance},
  author={Astrid Eijkelenboom and Boudewijn M. T. Burgering},
  journal={Nature Reviews Molecular Cell Biology},
  year={2013},
  volume={14},
  pages={83-97}
}
Forkhead box O (FOXO) transcription factors are involved in the regulation of the cell cycle, apoptosis and metabolism. In model organisms, FOXO activity also affects stem cell maintenance and lifespan as well as age-related diseases, such as cancer and diabetes. Multiple upstream pathways regulate FOXO activity through post-translational modifications and nuclear–cytoplasmic shuttling of both FOXO and its regulators. The diversity of this upstream regulation and the downstream effects of FOXOs… 
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