FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).

@article{Horst2004FOXO4IA,
  title={FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).},
  author={Armando A van der Horst and Leon G.J Tertoolen and Lydia M M de Vries-Smits and Roy A. Frye and Ren{\'e} H Medema and Boudewijn M. T. Burgering},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 28},
  pages={28873-9}
}
FOXO transcription factors have important roles in metabolism, cellular proliferation, stress tolerance, and aging. FOXOs are negatively regulated by protein kinase B/c-Akt-mediated phosphorylation. Here we show that FOXO factors are also subject to regulation by reversible acetylation. We provide evidence that the acetyltransferase CREB-binding protein (CBP) binds FOXO resulting in acetylation of FOXO. This acetylation inhibits FOXO transcriptional activity. Binding of CBP and acetylation are… CONTINUE READING

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