FOXO3a mediates signaling crosstalk that coordinates ubiquitin and atrogin-1/MAFbx expression during glucocorticoid-induced skeletal muscle atrophy.

@article{Zheng2010FOXO3aMS,
  title={FOXO3a mediates signaling crosstalk that coordinates ubiquitin and atrogin-1/MAFbx expression during glucocorticoid-induced skeletal muscle atrophy.},
  author={Bin Zheng and Sakae Ohkawa and Haiyan Li and Tiffany K. Roberts-Wilson and Stephen R Price},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2010},
  volume={24 8},
  pages={
          2660-9
        }
}
Muscle atrophy is a consequence of chronic diseases (e.g., diabetes) and glucocorticoid-induced insulin resistance that results from enhanced activity of the ubiquitin-proteasome pathway. The PI3K/Akt pathway inhibits the FOXO-mediated transcription of the muscle-specific E3 ligase atrogin-1/MAFbx (AT-1), whereas the MEK/ERK pathway increases Sp1 activity and ubiquitin (UbC) expression. The observations raise a question about how the transcription of these atrogenes is synchronized in atrophic… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 56 CITATIONS, ESTIMATED Infinity% COVERAGE

56 Citations

0510'11'13'15'17'19
Citations per Year
Semantic Scholar estimates that this publication has 56 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…