FOXO3a is a major target of inactivation by PI3K/AKT signaling in aggressive neuroblastoma.

  title={FOXO3a is a major target of inactivation by PI3K/AKT signaling in aggressive neuroblastoma.},
  author={Evan E. Santo and Peter J M Stroeken and Peter van Sluis and Jan Koster and Rogier Versteeg and Ellen M. Westerhout},
  journal={Cancer research},
  volume={73 7},
Neuroblastoma is a pediatric tumor of the peripheral sympathetic nervous system with a highly variable prognosis. Activation of the phosphoinositide 3-kinase (PI3K)/AKT pathway in neuroblastoma is correlated with poor patient prognosis, but the precise downstream effectors mediating this effect have not been determined. Here we identify the forkhead transcription factor FOXO3a as a key target of the PI3K/AKT pathway in neuroblastoma. FOXO3a expression was elevated in low-stage neuroblastoma… CONTINUE READING
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