FOXO3A genotype is strongly associated with human longevity.

@article{Willcox2008FOXO3AGI,
  title={FOXO3A genotype is strongly associated with human longevity.},
  author={Bradley J. Willcox and Timothy A. Donlon and Qimei He and Randi Chen and John Sinclair Grove and Katsuhiko Yano and Kamal H. Masaki and Donald Craig Willcox and Beatriz L. Rodr{\'i}guez and Jess David Curb},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 37},
  pages={13987-92}
}
Human longevity is a complex phenotype with a significant familial component, yet little is known about its genetic antecedents. Increasing evidence from animal models suggests that the insulin/IGF-1 signaling (IIS) pathway is an important, evolutionarily conserved biological pathway that influences aging and longevity. However, to date human data have been scarce. Studies have been hampered by small sample sizes, lack of precise phenotyping, and population stratification, among other… CONTINUE READING
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