FOXO3-mediated up-regulation of Bim contributes to rhein-induced cancer cell apoptosis

  title={FOXO3-mediated up-regulation of Bim contributes to rhein-induced cancer cell apoptosis},
  author={Jiao Wang and Shu Liu and Yancun Yin and Mingjin Li and Bo Wang and Li Yang and Yangfu Jiang},
The anthraquinone compound rhein is a natural agent in the traditional Chinese medicine rhubarb. Preclinical studies demonstrate that rhein has anticancer activity. Treatment of a variety of cancer cells with rhein may induce apoptosis. Here, we report that rhein induces atypical unfolded protein response in breast cancer MCF-7 cells and hepatoma HepG2 cells. Rhein induces CHOP expression, eIF2α phosphorylation and caspase cleavage, while it does not induce glucose-regulated protein 78 (GRP78… CONTINUE READING


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