FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3.

  title={FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3.},
  author={Judith Hagenbuchner and Andrey Kuznetsov and Martin Hermann and Barbara Hausott and Petra Obexer and Michael J. Ausserlechner},
  journal={Journal of cell science},
  volume={125 Pt 5},
FOXO transcription factors induce apoptosis and regulate cellular production of reactive oxygen species (ROS). To identify the sequence of molecular events underlying FOXO3 (FKHRL1)-induced apoptosis, we studied the regulation and function of FOXO3 by expressing an ECFP-tagged FOXO3 or a 4OH-tamoxifen (4OHT)-inducible FOXO3-ERtm fusion protein in SH-EP and STA-NB15 neuronal cells. After knockdown of FOXO3 or expression of a dominant-negative FOXO3 mutant we observed that etoposide- and… CONTINUE READING
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