FOXO1 involvement in insulin resistance-related pro-inflammatory cytokine production in hepatocytes

Abstract

Low-grade inflammation from hepatocytes plays a causal role in hepatic and systemic insulin resistance (IR). We aimed to explore whether and how FOXO1 was involved in IR-related inflammation in hepatocytes. We determined FOXO1 expression and activity, insulin and NF-κB signaling, and pro-inflammatory cytokine production in tumor necrosis factor-α (TNF… (More)
DOI: 10.1007/s00011-011-0417-3

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