FOXO1 inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasion.

@article{Zhang2011FOXO1IR,
  title={FOXO1 inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasion.},
  author={Haijun Zhang and Yunqian Pan and Li Zheng and Chung-youl Choe and Bruce Lindgren and E. Douglas Jensen and Jennifer J Westendorf and Liang Cheng and Haojie Huang},
  journal={Cancer research},
  year={2011},
  volume={71 9},
  pages={3257-67}
}
Prostate cancer patients with regional lymph node involvement at radical prostatectomy often experience disease progression to other organs, with the bone as the predominant site. The transcription factor Runx2 plays an important role in bone formation and prostate cancer cell migration, invasion, and metastasis. Here we showed that the forkhead box O (FOXO1) protein, a key downstream effector of the tumor suppressor PTEN, inhibits the transcriptional activity of Runx2 in prostate cancer cells… CONTINUE READING
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