FOXO1 in the ventromedial hypothalamus regulates energy balance.

Abstract

The transcription factor FOXO1 plays a central role in metabolic homeostasis by regulating leptin and insulin activity in many cell types, including neurons. However, the neurons mediating these effects and the identity of the molecular targets through which FOXO1 regulates metabolism remain to be defined. Here, we show that the ventral medial nucleus of… (More)
DOI: 10.1172/JCI62848

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