FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis.

@article{Alikhani2005FOXO1FA,
  title={FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis.},
  author={Mani Alikhani and Zoubin Alikhani and Dana T Graves},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 13},
  pages={12096-102}
}
Tumor necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory and pro-apoptotic mediator that plays an important role in several normal and disease processes. TNF-induced cell death is one of the principal mechanisms by which cells are removed. Although TNF-mediated apoptosis has been the subject of intense investigation, the transcriptional mechanisms through which it promotes apoptosis are not well understood and, paradoxically, the archetypal TNF-induced nuclear factor NFkappaB is… CONTINUE READING
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