FOXO1 couples metabolic activity and growth state in the vascular endothelium

  title={FOXO1 couples metabolic activity and growth state in the vascular endothelium},
  author={Kerstin Wilhelm and Katharina Happel and Guy Eelen and Sandra Schoors and Mark F. Oellerich and Radiance Lim and Barbara Zimmermann and Irene M. Aspalter and Claudio A. Franco and Thomas Boettger and Thomas Braun and Marcus Fruttiger and K. Rajewsky and Charles Keller and Jens C. Br{\"u}ning and Holger Gerhardt and Peter Carmeliet and Michael Potente},
Endothelial cells (ECs) are plastic cells that can switch between growth states with different bioenergetic and biosynthetic requirements. Although quiescent in most healthy tissues, ECs divide and migrate rapidly upon proangiogenic stimulation. Adjusting endothelial metabolism to the growth state is central to normal vessel growth and function, yet it is poorly understood at the molecular level. Here we report that the forkhead box O (FOXO) transcription factor FOXO1 is an essential regulator… CONTINUE READING
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warburg did not anticipate

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