FOXO1 activates glutamine synthetase gene in mouse skeletal muscles through a region downstream of 3'-UTR: possible contribution to ammonia detoxification.

@article{Kamei2014FOXO1AG,
  title={FOXO1 activates glutamine synthetase gene in mouse skeletal muscles through a region downstream of 3'-UTR: possible contribution to ammonia detoxification.},
  author={Yasutomi Kamei and Maki Hattori and Yukino Hatazawa and Tomomi Kasahara and Masanobu Kanou and Sayaka Kanai and Xunmei Yuan and Takayoshi Suganami and Wouter H. Lamers and Tadahiro Kitamura and Yoshihiro Ogawa},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2014},
  volume={307 6},
  pages={
          E485-93
        }
}
Skeletal muscle is a reservoir of energy in the form of protein, which is degraded under catabolic conditions, resulting in the formation of amino acids and ammonia as a byproduct. The expression of FOXO1, a forkhead-type transcription factor, increases during starvation and exercise. In agreement, transgenic FOXO1-Tg mice that overexpress FOXO1 in skeletal muscle exhibit muscle atrophy. The aim of this study was to examine the role of FOXO1 in amino acid metabolism. The mRNA and protein… 
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Mechanism of Gene Regulation in Skeletal Muscle Function

  • Y. Kamei
  • Biology, Medicine
    Nippon Eiyo Shokuryo Gakkaishi
  • 2022
This work has been investigating the role of a transcription factor, FOXO 1, which plays important roles in exercise, energy expenditure and glucose/amino acid metabolism, and glucose uptake in skeletal muscle.

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