FOXO1/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH.

@article{Liu2013FOXO13DI,
  title={FOXO1/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH.},
  author={Zhilin Liu and Diego H. Castrillon and Wei Zhou and Joanne S Richards},
  journal={Molecular endocrinology},
  year={2013},
  volume={27 2},
  pages={238-52}
}
The Forkhead boxO (FOXO) transcription factors regulate multiple cellular functions. FOXO1 and FOXO3 are highly expressed in granulosa cells of ovarian follicles. Selective depletion of the Foxo1 and Foxo3 genes in granulosa cells of mice reveals a novel ovarian-pituitary endocrine feedback loop characterized by: 1) undetectable levels of serum FSH but not LH, 2) reduced expression of the pituitary Fshb gene and its transcriptional regulators, and 3) ovarian production of a factor(s) that… CONTINUE READING

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