FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer.

@article{Modur2002FOXOPR,
  title={FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer.},
  author={Vijayanand Modur and Rakesh Nagarajan and Bernard Mark Evers and Jeffrey D. Milbrandt},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 49},
  pages={
          47928-37
        }
}
Mutations in PTEN occur in 60-80% of prostate cancers and lead to a constitutive activation of the phosphatidylinositol 3-kinase pathway and a resultant loss of activity of the FOXO family of forkhead transcription factors FKHRL1 and FKHR. To provide insight into the role of PTEN mutations in prostate cancer, we used microarrays to identify genes regulated by FKHRL1 and FKHR in LAPC4 prostate carcinoma cells. These studies revealed that adenoviral overexpression of FKHRL1 and FKHR in the LAPC4… CONTINUE READING
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