FOXO/Fringe is necessary for maintenance of the germline stem cell niche in response to insulin insufficiency.

@article{Yang2013FOXOFringeIN,
  title={FOXO/Fringe is necessary for maintenance of the germline stem cell niche in response to insulin insufficiency.},
  author={S Yang and Wen-Der Wang and C. Y. Chen and Chen-Yuan Tseng and Y Chen and Hwei-Jan Hsu},
  journal={Developmental biology},
  year={2013},
  volume={382 1},
  pages={124-35}
}
The stem cell niche houses and regulates stem cells by providing both physical contact and local factors that regulate stem cell identity. The stem cell niche also plays a role in integrating niche-local and systemic signals, thereby ensuring that the balance of stem cells meets the needs of the organism. However, it is not clear how these signals are merged within the niche. Nutrient-sensing insulin/FOXO signaling has been previously shown to directly control Notch activation in the Drosophila… CONTINUE READING

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