FOXM1b, which is present at elevated levels in cancer cells, has a greater transforming potential than FOXM1c

@inproceedings{Lam2013FOXM1bWI,
  title={FOXM1b, which is present at elevated levels in cancer cells, has a greater transforming potential than FOXM1c},
  author={Andy K. Y. Lam and Adaline W. L. Ngan and Man-Hong Leung and Davis C. T. Kwok and Vincent Wing Sun Liu and David Wai Chan and Wai Y Leung and Kwok-Ming Yao},
  booktitle={Front. Oncol.},
  year={2013}
}
The forkhead box (FOX) M1 transcription factor is required to maintain the proliferation of cancer cells. Two transcriptionally active isoforms of FOXM1, FOXM1b and FOXM1c, have been identified, but their functional differences remain unclear. FOXM1c is distinguished from FOXM1b by an extra exon (exon Va) that contains an ERK1/2 target sequence. Based on a literature search and quantitative PCR analysis, we concluded that FOXM1b is the predominant isoform that is overexpressed in cancers. The… CONTINUE READING
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