FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance

  title={FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance},
  author={Pasarat Khongkow and Upekha Karunarathna and Mattaka Khongkow and Chun Gong and Ana Rita Gomes and Ernesto Yag{\"u}e and Lara J Monteiro and Mesayamas Kongsema and Stefania Zona and Ellen P. S. Man and Janice W.-H. Tsang and R C Coombes and Kou-Juey Wu and U. S. Khoo and Ren{\'e} H Medema and Raimundo Freire and Eric W-F Lam},
FOXM1 is implicated in genotoxic drug resistance but its mechanism of action remains elusive. We show here that FOXM1-depletion can sensitize breast cancer cells and mouse embryonic fibroblasts (MEFs) into entering epirubicin-induced senescence, with the loss of long-term cell proliferation ability, the accumulation of γH2AX foci, and the induction of senescence-associated β-galactosidase activity and cell morphology. Conversely, reconstitution of FOXM1 in FOXM1-deficient MEFs alleviates the… CONTINUE READING
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