FOXM1 is a transcriptional target of ERα and has a critical role in breast cancer endocrine sensitivity and resistance


In this study, we investigated the regulation of FOXM1 expression by estrogen receptor α (ERα) and its role in hormonal therapy and endocrine resistance. FOXM1 protein and mRNA expression was regulated by ER-ligands, including estrogen, tamoxifen (OHT) and fulvestrant (ICI182780; ICI) in breast carcinoma cell lines. Depletion of ERα by RNA interference… (More)
DOI: 10.1186/bcr2499


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