FOXM1 expression mediates growth suppression during terminal differentiation of HO‐1 human metastatic melanoma cells

@article{Hunh2011FOXM1EM,
  title={FOXM1 expression mediates growth suppression during terminal differentiation of HO‐1 human metastatic melanoma cells},
  author={Kim Mai Huỳnh and Jae Won Soh and Rupesh Dash and Devanand Sarkar and Paul B Fisher and Dongchul Kang},
  journal={Journal of Cellular Physiology},
  year={2011},
  volume={226}
}
Induction of terminal differentiation represents a potentially less toxic cancer therapy. Treatment of HO‐1 human metastatic melanoma cells with IFN‐β plus mezerein (MEZ) promotes terminal differentiation with an irreversible loss of growth potential. During this process, the transcription factor FOXM1 is down‐regulated potentially inhibiting transactivation of target genes including those involved in G2/M progression and cell proliferation. We investigated the mechanism of FOXM1 down… 
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