FOXL2 molecular testing in ovarian neoplasms: diagnostic approach and procedural guidelines

@article{Kommoss2013FOXL2MT,
  title={FOXL2 molecular testing in ovarian neoplasms: diagnostic approach and procedural guidelines},
  author={Stefan Kommoss and Michael S Anglesio and Robertson Mackenzie and Winnie Yang and Janine Senz and Julie Ho and Lynda L Bell and Sylvia Lee and Julie Lorette and David G. Huntsman and Cyril Blake Gilks},
  journal={Modern Pathology},
  year={2013},
  volume={26},
  pages={860-867}
}
A single, recurrent somatic point mutation (402CG) in FOXL2 has been described in almost all adult-type granulosa cell tumors but not other ovarian neoplasms. Histopathological features of adult-type granulosa cell tumors can be mimicked by a variety of other tumors, making diagnosis of adult-type granulosa cell tumor challenging. It has been suggested that molecular testing for FOXL2 mutation might be a useful tool in the diagnosis of adult-type granulosa cell tumors. The aim of this study… CONTINUE READING
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