FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.

@article{Freyaldenhoven2002FOXD4aAF,
  title={FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.},
  author={B. Freyaldenhoven and Cora Fried and K. Wielckens},
  journal={Gene},
  year={2002},
  volume={294 1-2},
  pages={
          131-140
        }
}
Winged helix factors are important regulators of embryonal development and tissue differentiation. They are also involved in translocations found in acute leukemias and solid tumors. We have detected transcripts from five known and four novel winged helix genes in leukemia cell lines and CD34(+) blood progenitor cells by reverse trancription-polymerase chain reaction with degenerate primers on the highly conserved DNA binding domain. The genomic clones coding for two new winged helix proteins… Expand
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