FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity.

@article{Krishnakumar2016FOXD3RP,
  title={FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity.},
  author={Raga Krishnakumar and Amy F Chen and Marisol G Pantovich and Muhammad Danial and Ronald J. Parchem and Patricia A. Labosky and Robert Blelloch},
  journal={Cell stem cell},
  year={2016},
  volume={18 1},
  pages={
          104-17
        }
}
Early development is governed by the ability of pluripotent cells to retain the full range of developmental potential and respond accurately to developmental cues. This property is achieved in large part by the temporal and contextual regulation of gene expression by enhancers. Here, we evaluated regulation of enhancer activity during differentiation of embryonic stem to epiblast cells and uncovered the forkhead transcription factor FOXD3 as a major regulator of the developmental potential of… CONTINUE READING

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