FOXA1 is a critical determinant of Estrogen Receptor function and endocrine response

@inproceedings{Hurtado2011FOXA1IA,
  title={FOXA1 is a critical determinant of Estrogen Receptor function and endocrine response},
  author={A. Huete Hurtado and Kelly A. Holmes and Caryn S. Ross-Innes and Dominic Schmidt and Jason S. Carroll},
  booktitle={Nature Genetics},
  year={2011}
}
Estrogen receptor-α (ER) is the key feature of most breast cancers and binding of ER to the genome correlates with expression of the Forkhead protein FOXA1 (also called HNF3α). Here we show that FOXA1 is a key determinant that can influence differential interactions between ER and chromatin. Almost all ER-chromatin interactions and gene expression changes depended on the presence of FOXA1 and FOXA1 influenced genome-wide chromatin accessibility. Furthermore, we found that CTCF was an upstream… CONTINUE READING

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