FOS-1 functions as a transcriptional activator downstream of the C. elegans JNK homolog KGB-1.


JNK proteins are conserved stress-activated MAP kinases. In C. elegans, the JNK-homolog KGB-1 plays essential roles in protection from heavy metals and protein folding stress. However, the contributions of KGB-1 are age-dependent, providing protection in larvae, but reducing stress resistance and shortening lifespan in adults. Attenuation of DAF-16 was… (More)
DOI: 10.1016/j.cellsig.2016.11.010