• Corpus ID: 212599434

FORMULATION DEVELOPMENT OF NANOSTRUCTURED LIPID CARRIER LOADED EMULGEL OF BUTENAFINE HYDROCHLORIDE

@inproceedings{Gondkar2019FORMULATIONDO,
  title={FORMULATION DEVELOPMENT OF NANOSTRUCTURED LIPID CARRIER LOADED EMULGEL OF BUTENAFINE HYDROCHLORIDE},
  author={S. B. Gondkar and Sonali D. Yelmame and Ravindra Bhanudas Saudagar},
  year={2019}
}

• S. B. Gondkar, Sonali D. Yelmame, R. Saudagar
• Published 2019
• Chemistry

The aim of the study was to prepare and evaluate emulgel incorporating the Nanostructured Lipid Carrier (NLC) of Butenafine HCl for the localized delivery of the active ingredient after topical application. Butenafine HCl has been used as model drugs for the treatment of the fungal infection. Butenafine HCl loaded NLC was designed for topical administration, were prepared by the hot high pressure homogenization technique. This Butenafine loaded NLC was characterized for particle size, zeta potential, entrapment efficiency and SEM. The lipid nanoparticles were then incorporated in gel for convenient topical application and were evaluated for particle size, rheology analysis, texture analysis, in vitro drug release studies and ex vitro skin permeation studies. The preparation of NLC dispersion with a mean particle size 272.9 nm has been obtained with uniform size distribution (PI <0.518). It was observed that prepared NLC formulation showed that sustained activity for 24hr as compared to the conventional cream which was 12hr. Research work could be concluded as successful development of Butenafine HCl loaded NLC in emulgel formulation.