Corpus ID: 52066465

FORMULATION AND EVALUATION OF PIROXICAM LIQUISOLID COMPACTS

@inproceedings{Jabbar2013FORMULATIONAE,
  title={FORMULATION AND EVALUATION OF PIROXICAM LIQUISOLID COMPACTS},
  author={A. Jabbar and A. Hussein},
  year={2013}
}
Objective: The purpose of the present research was to investigate the in vitro dissolution properties of poorly water soluble piroxicam by utilizing liquisolid technique. Different liquisolid (LS) compacts were prepared using a mathematical model to calculate the required quantities of powder and liquid ingredients to produce acceptably flowable and compressible admixture. Methods: Avicel PH 102, Aerosil 200 and croscarmellose sodium were employed as carrier, coating material and disintegrant… Expand

Figures and Tables from this paper

FORMULATION AND CHARACTERIZATION OF PIROXICAM LIQUISOLID TECHNIQUE FOR SOLUBILITY ENHANCEMENT
This present study an attempt was made to formulate poorly water soluble drug i.e.,piroxicam to enhance the dissolution rate of piroxicam by liquisolid systems. Based on the solubility studies theExpand
ENHANCEMENT OF SOLUBILITY OF LORNOXICAM USING NOVEL LIQUISOLID TECHNIQUE
Lornoxicam is amorphous substance, widely used in the treatment of Rhumatoid Arthritis (RA). It is a BCS class II drug, practically insoluble in water exhibiting poor dissolution pattern and low oralExpand
FORMULATION AND EVALUATION OF CANDESARTAN IMMEDIATE RELEASE TABLETS BY USING LIQUISOLID TECHNIQUE
The aim of this study is to develop a novel liquid-solid technique to enhance the dissolution rate of poorly water soluble drug of candesartan, which is a BCS class II drug. The technique is basedExpand
Formulation and In-Vitro Evaluation of Liquisolid Compact of Pioglitazone HCL
The purpose of the study was to formulate liquisolid tablets of Pioglitazone hydrochloride to improve the solubility and dissolution rate. The λmax of Pioglitazone hydrochloride was found to be 234nmExpand
Enhancement of Dissolution Rate of Gliclazide by Liquisolid Technique
The purpose of the present research was to investigate the in vitro dissolution properties of poorly water soluble gliclazide by utilizing liquisolid technique. Avicel PH 102 and Neusilin wereExpand
FORMULATION AND EVALUATION OF LIQUISOLID COMPACT OF EPROSARTAN MESYLATE
Liquisolid technique is a new approach for delivery of drugs through oral cavity. This technique is suitable for poorly or water insoluble drugs and also for immediate or sustained releaseExpand
SOLUBILITY ENHANCEMENT OF MELOXICAM BY LIQUISOLID TECHNIQUE AND ITS CHARACTERIZATION Janakidevi Sirisolla A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam. Andhra Pradesh, India
Solubility is the important parameter to design a dosage form; it is very difficult to formulate an insoluble drug in to final formulation. In This present study deals with the enhancement ofExpand
Evaluation of thermal treating on release rate of theophylline from Eudragit RS and HPMC K4M containing liquisolid systems
TLDR
The liquisolid technique could be used for design controlled release systems based on thermal treating effect on polymer structure, which showed significant decrease in drug release from Eudragit RS containing liquisolic systems. Expand
DISSOLUTION RATE ENHANCEMENT OF A POORLY SOLUBLE DRUG AMLODIPINE BESYLATE USING LIQUISOLID COMPACTION METHOD
Article history Amlodipine besylate is a vasodilator in which reduces blood pressure. Since, the drug has low bioavailability, it can be increased by enhancing solubility in stomach. The Liqui-SolidExpand
Solid state behavior of progesterone and its release from Neusilin US2 based liquisolid compacts
Abstract The aim of present work was to investigate the role of liquisolid technique in improving dissolution of high dose Progesterone. Progesterone-PEG 400 dispersions were prepared and evaluatedExpand
...
1
2
...

References

SHOWING 1-10 OF 50 REFERENCES
In vitro release evaluation of hydrocortisone liquisolid tablets.
TLDR
The in vitro drug dissolution rates of liquisolid tablets were found to be consistent and independent of the volume of dissolution medium used, in contrast to the plain tablets which exhibited declining drug release patterns with decreasing dissolution volumes. Expand
Enhancement of dissolution rate of piroxicam using liquisolid compacts.
TLDR
The results showed that liquisolid compacts demonstrated significantly higher drug release rates than those of conventionally made (capsules and directly compressed tablets containing micronized piroxicam) due to an increase in wetting properties and surface of drug available for dissolution. Expand
Enhancement of prednisolone dissolution properties using liquisolid compacts
The in-vitro release characteristics of prednisolone, a very slightly water soluble glucocorticoid, formulated in directly compressed tablets and liquisolid compacts, were studied at differentExpand
Enhancement of famotidine dissolution rate through liquisolid tablets formulation: in vitro and in vivo evaluation.
  • R. Fahmy, M. Kassem
  • Chemistry, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2008
TLDR
The bioavailability study indicated that the prepared optimal liquisolid formula did not differ significantly from the marketed famotidine tablets concerning Cmax, tmax, and AUC(0-8) at P<0.05. Expand
Effect of powder substrate on the dissolution properties of methyclothiazide liquisolid compacts.
TLDR
It was observed that maximum drug dissolution rates can be exhibited by systems that have powder substrates with optimum carrier-to-coating ratios and liquisolid tablets displayed significantly enhanced dissolution profiles compared to those of marketed products. Expand
Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical properties
TLDR
The results showed that liquisolid formulations exhibited significantly higher drug dissolution rates at pH 1.2 and 7.2 compared to compacts prepared by the direct compression technique, probably due to an increase in wetting properties and surface area of drug particles available for dissolution. Expand
The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug (indomethacin) from liquisolid compacts.
TLDR
The liquisolid compacts technique can be a promising alternative for the formulation of water insoluble drugs, such as indomethacin into rapid release tablets. Expand
Powdered Solution Technology: Principles and Mechanism
TLDR
A theoretical model based on the principles and mechanism of powdered solutions is presented and a new physical property of powders termed the flowable liquid-retention potential (Φ value) is introduced and is shown to be superior to previously reported studies in optimizing the amount of excipients needed to prepare powdered solutions with acceptable flow properties. Expand
Effects of Grinding with Microcrystalline Cellulose and Cyclodextrins on the Ketoprofen Physicochemical Properties
TLDR
The results pointed out the importance of the carrier nature on the efficiency of the cogrinding process as both cyclodextrins were much more effective than was microcrystalline cellulose, even though no true inclusion complex formation occurred by mechanochemical activation. Expand
Design and Evaluation of Orodispersible Tablet of Aceclofenac Using Different Superdisintegrants by 23 Factorial Designs
In the present work, Orodispersible tablet of Aceclofenac were designed with a view to Enhance patient compliance. A combination of superdisintegrants i.e.Ac-di-sol (Croscarmellose sodium),Expand
...
1
2
3
4
5
...