• Corpus ID: 138997369

FORMULATION AND EVALUATION OF CARBAMAZEPINE EXTENDED RELEASE TABLETS USP 200MG

@inproceedings{Mohammed2012FORMULATIONAE,
  title={FORMULATION AND EVALUATION OF CARBAMAZEPINE EXTENDED RELEASE TABLETS USP 200MG},
  author={Fasiuddin Arif Mohammed and Rama Raju},
  year={2012}
}
The objective of this research work was to formulate and evaluate the extended release tab lets containing 200mg of Carbamazepine. Different excipients were tested for their compatibility with Carbamazepine, which reve aled that there is no physical and chemical interaction occurred. Extende d release tablets were formulated by Wet Granulatio n method incorporating HPMC K4M, a hydrophilic polymer, Dicalcium phosphate (Anhydrous) as diluent, Povidone (K-30) as Binder , Colloidal silicon dioxide… 
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References

SHOWING 1-9 OF 9 REFERENCES
Formulation and in vitro/in vivo investigation of carbamazepine controlled-release matrix tablets.
TLDR
Developed formulation (HPMC-10) was found to be bioequivalent to Tegretol CR 200 and, controlled release was obtained with smoother concentration-time curve resulting in less fluctuations.
CHEMICAL STABILITY STUDIES OF BIOADHESIVE TOPICAL GEL
TLDR
BNTG3 was successfully developed and standardized for improved topical therapeutics and will be more effective and stable if it is stored at or below 25±2°C.
Clinical Pharmacokinetics of Carbamazepine
TLDR
A single daily dose of carbamazepine is insufficient; 2 doses per day are appropriate in most cases, but some patients may benefit from more frequent dosing to avoid side-effects.
Handbook of Pharmaceutical Excipients
The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and
Improved CNS tolerability following conversion from immediate‐ to extended‐release carbamazepine
TLDR
Tolerability of ‘narrow therapeutic ratio’ (NTR) antiepileptic drugs may improve with uniform drug delivery with determination of whether conversion from immediate‐release carbamazepine to extended‐release CARZ decreased the incidence of CNS side‐effects associated with drug concentration oscillations.
Oral extended-release products
The use of extended-release products offers some potential advantages in patient convenience/compliance and therapeutic outcomes.
Epilepsy: contemporary perspectives on evaluation and treatment.
  • G. Cascino
  • Medicine, Psychology
    Mayo Clinic proceedings
  • 1994
A Proposed Diagnostic Scheme for People with Epileptic Seizures and with Epilepsy: Report of the ILAE Task Force on Classification and Terminology
  • J. Engel
  • Psychology, Medicine
    Epilepsia
  • 2001
TLDR
A diagnostic scheme that makes use of standardized terminology and concepts to describe individual patients is proposed, and a variety of approaches to classification are possible, and some are presented here by way of example only.